13 Naloxone is indicated for the rapid reversal of these symptoms of central nervous system depression in opioid overdose. 3, 13 If untreated, this can progress to vomiting, absent pulse and breathing, loss of consciousness, and even death.

3 When taken in large quantities, opioid medications such as morphine, hydromorphone, methadone, heroin, or fentanyl are capable of causing life-threatening symptoms such as respiratory depression, reduced heart rate, slurred speech, drowsiness, and constricted pupils.

3 More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors. Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv Generic Name Naloxone DrugBank Accession Number DB01183 Background

Morphine antidote